The mother-of-14, who was dubbed 'Octomom' after giving birth to octuplets last year, will reportedly feature on the April 20 instalment of the chatshow.
Speaking to Entertainment Weekly, a representative for Winfrey's Harpo Productions said: "Viewers will see a day in the life of Nadya and her family, and Oprah speaks with Nadya via satellite from her home."
Suleman's lawyer was apparently the first to break the news, telling the Orange County Register that a camera crew had spent a night filming at her home.
"They were essentially filming the nitty gritty. She pretty much had a camera in her face the whole time," he is quoted as saying.