The ITV series, in which the ghost of Hopkirk helps his partner Randall to solve crimes, originally ran from 1969 to 1970. A remake aired from 2000 to 2001.
Syfy has now signed a deal to develop a pilot for a one-hour scripted series based on the concept.
Scrubs executive producer Josh Bycel and Jonathan Fener, who has previously worked on American Dad, will write and executive produce the project, which will be made by ITV Studios.
The executive vice-president of original programming for Syfy Mark Stern said: "Josh and Jonathan have found a great way to update the buddy cop formula with a supernatural twist. We look forward to working with them, [the other executive producer] Howard [Braunstein] and ITV to bring new life to this British classic."