Most of the new series, renewals and cancelations had been confirmed over the last week, leaving the announcement to serve as a confirmation of the shape the schedule will take.
With The Jay Leno Show to replace on five nights of the week, the haul of new series was predictably large at a tally of 13: seven dramas, five comedies and one reality show.
Monday nights will be an action-themed affair on NBC from the Fall, starting with Chuck as a lead-in to new thriller The Event and Jerry Bruckheimer's Chase.
Tuesdays remain intact, with The Biggest Loser paired alongside Lauren Graham dramedy Parenthood.
On Wednesdays, Law & Order: SVU is sandwiched between new JJ Abrams spy drama Undercovers and new spinoff Law & Order: Los Angeles.
Thursday's popular comedy block undergoes some changes in 2010-11, with 30 Rock moving to an earlier timeslot of 8.30pm to make way for Outsourced, a new comedy set at an Indian call centre. Community and The Office air at 8pm and 9pm respectively, while Parks & Recreation is shunted to midseason. Hour-long comedy Love Bites debuts at 10pm.
Fridays see the return of Who Do You Think You Are for a second season, sharing the 8pm hour with new reality series School Pride, which follows community efforts to repair struggling schools. New Jimmy Smits legal drama Outlaw sits after Dateline.
New dramas being saved for midseason include The Cape and Harry's Law, while new midseason comedies include Perfect Couples, The Paul Reiser Show and Friends With Benefits.
Notable axings include Law & Order after 20 seasons, cult drama Heroes and 2009-10's two freshman medical efforts, Trauma and Mercy.
> Scorecard: What's in and out at NBC
> Night By Night: NBC's 2010-11 lineup