As is traditional, the Thursday programme is film-heavy, with panels for TRON: Legacy, Angelina Jolie's Salt and Battle: Los Angeles.
Also featured are The Expendables and RED, plus TV shows Psych, White Collar and Dexter.
JJ Abrams and Joss Whedon will participate in a joint discussion session, while True Blood author Charlaine Harris has also been tapped for a spotlight panel.
The Nikita pilot will be screened the previous evening as part of the annual Preview Night.
Comic-Con runs July 21-25 in San Diego, CA.