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Zuicker was heavily involved with the first four seasons of the crime drama but later took a step back from the series to focus on new projects. His most recent written contribution to the franchise was a 2006 CSI: NY episode.
The producer told Deadline: "The main reason I went back to CSI is to write with my partner in crime Carol Mendelsohn. Over the first five seasons, we've written many, many scripts together. We have so much fun writing the show. And when I went off to develop, I really missed the day-to-day action of writing episodic television."
Zuicker promised that the new season will be "explosive" and dismissed fears for the programme's future following declining ratings.
"Today, CSI is watched by 73.8 million people [worldwide] a week. That's amazing." he said.
He added that forthcoming episodes will be "fun, Vegas-centric, and very character-driven".
CSI will return to CBS on September 23.
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