Hopkins's character Grayson began a romance with Jules (Courteney Cox) at the end of the first season.
However, the actor told Fancast that he is now looking forward to seeing the couple split up.
"When we left off, they were dating, but you know that's not going to last," he joked. "I can't wait for the break-up - I don't know how they're going to do it, but it's going to be fun."
The second season of Cougar Town will premiere on September 22 on ABC.
> Ryan Devlin returns to 'Cougar Town'