The programme - to be hosted by David Hasselhoff - will focus on those affected by the recent BP oil spill, with particular tributes given to the residents of Mississippi.
It will include musical performances filmed at Biloxi's Coast Coliseum with artists such as Brian McKnight, Lonestar, Taylor Hicks and Chris Massey, while Dean Cain, Shannon Elizabeth and B.B. King will also make appearances.
"[The Gulf Is Back will feature] moving real-life stories of the heroic actions taken by everyday people to overcome problems caused by the devastating oil spill," read a press release.
The special - which will be broadcast in HD - will air on August 27 on The CW.