Married to Rock will feature the wives of former Guns N' Roses member Duff McKagan, Jane's Addiction singer Perry Farrell and Billy Idol guitarist Steve Stevens.
The show will revolve around the introduction of AJ Celi, currently in a relationship with The Cult's Billy Duffy, who hopes to become a "rock wife" during the course of the series.
"So many women have a fantasy about landing a rock star," E!'s Lisa Berger told The Hollywood Reporter. "We're raising the curtain on the rock 'n' roll lifestyle."
The show, which will have an initial run of eight episodes, is scheduled to begin on November 7.