E! Online reports that the show, which stars Bill Paxton, Jeanne Tripplehorn, Chloe Sevigny and Ginnifer Goodwin, will end after the conclusion of its fifth season.
Creators Mark Olsen and Will Scheffer said in a statement: "When we created Big Love in 2002, we had a strong conception of the journey the Henrickson family would make over the course of the series, of the story we had to tell.
"While we were in the writers' room this year shaping our fifth season, we discovered that we were approaching the culmination of that story."
Sevigny, who plays one of the three Henrickson wives, said of the final run: "I think that finally you see the Henricksons having to deal with some consequences, for their actions and for their lifestyle. And they are finally getting a little bit of comeuppance."
The actress previously denounced the fourth season of Big Love as "awful".