Cast member Garret Dillahunt told The Hollywood Reporter that his character Burt kisses Sedaris on the programme.
"Amy Sedaris is coming in December to do the show," he revealed.
However, further details of Sedaris's role have not yet been released. The actress has previously appeared on shows including The Middle, The New Adventures Of Old Christine, The Closer and Sex And The City.
Dillahunt also revealed that he is pleased Raising Hope was picked up for a full season, saying: "I think it's a really good show. In this climate, there's no telling what's going to happen, but I thought it deserved it. I'm happy about it. And I don't die in it."
Raising Hope airs on Tuesdays at 9/8c on Fox.