A newspaper claimed that the actress, who plays Susan Mayer on the show, had informed producers of her decision to leave at the end of the current season.
However, Hatcher hit back at the "hurtful" claims on her official Facebook page and revealed that she will only leave the show when it is cancelled.
"There are not enough adjectives to describe how stupid, off base, and ridiculously untrue this is," she said. "'Newspapers' should be accountable for this kind of irresponsible journalism and reckless fabrication of a story. What disturbs me the most is that one fan would consider for one second that I would "quit" what has been one of the highlights of my career for which I am grateful on a daily basis.
"I have never said nor inferred otherwise. They made no effort to contact me or my representatives or the network to fact check. I am awaiting a retraction and apology at the least for mucking up everyone's Sunday with this huge, hurtful lie.
"I will say it again, I love Desperate Housewives, the cast and crew are like family and I am with it till it's cancelled.
Hatcher praised the show's latest addition Vanessa Williams and the writing team for continuing to make the ABC series popular with viewers.
"Vanessa Williams and the writers have brought a new energy to the show this year and I expect and hope it can continue on for a long time," she said.
"I meet many people who still find so much joy in watching it and I want everyone to know I'm joyful to be involved to this day and that's not going to change."