Lucretia (Lawless) will enter into a sexual relationship with her old friend Gaia (Jaime Murray) in the new six-part series.
"The lesbian stuff made me nervous as hell," the actress told TV Guide. "I don't think I could have done it without Jaime. She's really funny and 200% professional. She's my kind of woman!"
The former Xena star also admitted that she is pleased to be returning to the role of Lucretia for the second run of Spartacus: Blood and Sand, following the character's serious wounding at the conclusion of season one.
"This role is the greatest challenge and pleasure of my career," she insisted. "I'm grateful I escpaed my fate."
Spartacus: Gods Of The Arena begins tonight on Starz at 10/9c.