US TV
Rumours over the fate of the supernatural series had been rife for some time, with dwindling ratings and the announcement in January that its US broadcast network, The WB, would be merging with the rival UPN network.
"It's been a hell of a run, but all good things must come to an end," said executive producer Brad Kern.
The final episode will air Stateside on May 21 and in the UK on Living TV in June.
More: US TV
Tube Talk
'Freaks and Geeks': Tube Talk GoldTube Talk Gold heads back to the '80s and remembers Freaks and Geeks.
2012-13 Season
Blythe Danner for ABC's 'Gilded Lilys'Madeline Zima is also cast in the period drama pilot produced by Shonda Rhimes.
US TV Interviews
'Celebrity Apprentice' Debbie Gibson Q&ADebbie Gibson opens up about her Celebrity Apprentice experience.
US TV Ratings
'Blue Bloods', 'Grimm' rise on FridayCBS beats ABC to win Friday night's ratings battle, thanks to Blue Bloods.
