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TV Line reports that the star will appear in upcoming episode 'Nevada v. Greene' as Sally, a stand-up comedian who faces a lawsuit when she insults an audience member.
Griffin's recent acting credits include roles in Law & Order: Special Victims Unit, Privileged and Ugly Betty.
The Suddenly Susan star recently confirmed that she has decided to end her Bravo reality series My Life on the D-List after six seasons.
The Defenders returns to CBS this Friday at 8/7c. Griffin's episode is currently expected to air in March.
