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The annual post-Oscars broadcast will also feature appearances from stars including Jessica Alba, Eva Longoria, Kelly Ripa, Minka Kelly and Sofia Vergara.
Hanks will be on the show to unveil a clip from his new film Larry Crowne, which revolves around a man who attempts to reinvent his life by embarking on a new career.
Previous stars to appear on Kimmel's post-Academy Awards programme include Robert Downey Jr. and Mel Gibson, while it has also premiered comedy sketches such as 'I'm F**king Ben Affleck' and 'Handsome Men's Club'.
Jimmy Kimmel: Live After The Academy Awards airs Sunday, February 27 following the Oscars on ABC.
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