The 8-part series stars former Coronation Street star Sally Lindsay as Lisa, a married woman living in Manchester.
Lisa is unaware that another woman, Kate, is trying to seduce her husband Dan. She also has to keep her neighbour Bianca away and battles with her feelings for new resident Jack.
The show stars Daniel Ryan as Dan, while Liza Tarbuck will play Kate. The cast also includes Bobby Ball, Pauline Collins, Angela Griffin, Paula Wilcox, Sian Reeves, Adrian Bower, Neil Fitzmaurice and Owen McDonnell.
Sky1's head of comedy Lucy Lumsden said: "I'm delighted with the wealth of talent that surrounds Mount Pleasant both on and off screen. What better way to kick off Sky's plans for original British comedy? Our customers are in for a treat."
Production on Mount Pleasant has begun in Manchester and is expected to continue through June. The show is scheduled to air on Sky1 in the Autumn.