TV Line reports that the General Hospital star will appear in this season's 21st episode, 'Chuck vs. The Wedding Planner'.
LoCicero will play Daphne Peralta, a wedding planner from Jersey who crosses paths with Chuck (Zachary Levi) and new fiancée Sarah (Yvonne Strahovski).
The actress has previously appeared in episodes of Bones, Without A Trace and Joey, while her film credits include Rush Hour 2 and The Family Man.
Chuck airs on Mondays at 8/7c on NBC. LoCicero's appearance is expected to air in April.