The project will focus on Mary Beth (Minnie Driver), a single mother who teams up with a streetwise conman (Brandon T. Jackson) to solve crimes.
According to The Hollywood Reporter, DeWulf will play a character named Ingrid in the pilot, which has been written by Never Back Down director Jeff Wadlow.
The actress recently played recurring roles on Outsourced and Hawthorne. She has also made guest appearances on Chuck and CSI: NY.
Glee actor Stephen Tobolowsky and Without A Trace star Enrique Murciano will also appear in Hail Mary as a pair of detectives.
Jeff Wadlow will executive produce alongside Joel Silver and The L Word's Ilene Chaiken.