The comedy focuses on four assistants who work for a celebrity couple.
According to Deadline, Henrie has landed the lead role in the the project.
His character Mike moves to Hollywood from Pennsylvania and hopes that his new job as a celebrity's assistant will bring him new opportunities. Meanwhile, his colleagues have to teach him how to behave around his bosses.
Henrie plays Ted's son in How I Met Your Mother and has also appeared in shows including Wizards of Waverly Place and That's So Raven.
Assistants is in contention for CBS's 2011-2012 season.
> T.J. Miller joins CBS comedy pilot