The comedy stars Zooey Deschanel as Jessica, a teacher who moves in with three men after a difficult breakup.
Deadline says that Wayans Jr. will play one of Jessica's new roommates. His character Coach is described as a lazy and unfit trainer.
Wayans Jr. recently filmed the ABC series Happy Endings, which will premiere in the summer. His role in Chicks & D**ks is said to be in second position.
He has also appeared in My Wife And Kids and the movies Dance Flick and The Other Guys.
Chicks & D**ks will also star Jake M. Johnson and Max Greenfield.