The show will take the Thursday slot at 8.30/7.30c currently occupied by sitcom Perfect Couples.
The Paul Reiser Show is loosely based on the Mad About You star's real life and will focus on Reiser's antics as he makes a number of new male friends.
The show's debut casts further doubt on the future of Perfect Couples, which has so far attracted a season average of 3.27 million viewers.
Series star Kyle Bornheimer recently joined the cast of Fox pilot Council Of Dads, while his co-star David Walton signed up for a role in NBC comedy Bent.
> NBC interested in Paul Reiser pilot