The project, written by Tucker Cawley, will star Heather Locklear as Ali, a vapid celebrity.
Deadline reports that Jones will play Ali's handsome husband Gale, who lives in the shadow of his more successful wife.
He is best known for his role as a correspondent on The Daily Show and has also played recurring roles on How I Met Your Mother and Law & Order.
David Henrie and Sarah Wright will also appear in the potential series as two of the four eponymous assistants.
Two and a Half Men producers Eric and Kim Tannenbaum will executive produce The Assistants.
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