According to Entertainment Tonight, the Today Show anchor will leave the programme at the beginning of 2013 to pursue other projects.
The news comes just days after reports that his current Today Show co-host Meredith Vieira is considering resigning from the morning programme later this year in order to spend more time with her ailing husband.
Lauer's former NBC co-anchor and current CBS News host Katie Couric is also expected to leave her post and may go on to host her own syndicated talkshow.
"There seems to be an awful lot of speculation around news anchors these days, and it's not our practice to comment on any of it," said a rep for the Today Show on Wednesday. "Matt Lauer has a long-term contract with NBC News and Today."