The comedy, which is based on the memoirs of Chelsea Handler, stars Laura Prepon as an opinionated cocktail waitress called Chelsea.
TV Guide reports that Chelsea will meet Jones's character when she ends up in prison for drink-driving.
Jones's character is described as a "lesbian bully", but the pair become friends in an unusual way.
Jones is currently starring as Coach Beiste in Glee. She has also appeared in shows such as Married With Children, HawthoRNe, Nip/Tuck and Lizzie McGuire.
Are You There, Vodka? will also star Lenny Clarke, Angel Laketa Moore, Jo Koy and Mark Povinelli.
Handler is executive producing the project and has previously revealed that she will appear on screen as Chelsea's older sister.
Are You There, Vodka? It's Me, Chelsea is in contention for NBC's 2011-2012 season.