The comedy stars Michael Chiklis as Vince, a man who begins to speak completely honestly after a brain aneurysm.
Deadline reports that Fox will play Vince's youngest daughter in the project.
Fox previously appeared as Kayla in Desperate Housewives. She has also starred in several episodes of Melissa & Joey and has had guest roles in shows such as That's So Raven, iCarly and The New Adventures of Old Christine.
Vince Uncensored, which is being directed by Kelsey Grammer, will also feature Maz Jobrani, Georgia Engel and Elizabeth Perkins.
The project is in contention for ABC's 2011-2012 season.