The network announced on Wednesday that the Saturday Night Live star will act as the first 'Chief Shark Officer' for the summer event and will appear in several on-air wraps and specials.
"Shark Week is a summertime celebration. It's about being scared out of your swim trunks but it's also about being entertained and learning something new," said Discovery Channel president Clark Bunting in a statement.
"Andy Samberg, an incredibly talented comedian and innovator, is the perfect person to bring those elements together and represent Discovery for our biggest week of the year."
Samberg added: "I'm overjoyed about being appointed CSO. Everyone loves Shark Week. It's the Bill Cosby of week-long television blocks dedicated to sea animals."
Samberg recently joined the cast of the upcoming comedy Hand Job, which stars Parks and Recreation actress Aubrey Plaza and fellow SNL castmate Bill Hader.
He will also appear as Adam Sandler's son in I Hate You Dad.