The actor portrayed neurotic doctor John 'JD' Dorian for nine seasons on the medical sitcom alongside Sarah Chalke, Donald Faison and John C. McGinley.
Speaking to USA Today, Braff revealed that the laid-back nature of the Scrubs set was the breeding ground for the show's humour.
"It was the best job in the world, because you essentially went to work every day and laughed and acted like a goofball with all of your friends," he said. "A job doesn't get better than that."
The star added: "So if there's one thing I miss, it's hanging out with all those people and cracking up all day long. Just being silly. I'm still very close with a lot of them, and I miss hanging out with them every day."
Over the course of its near decade-long run, Scrubs received 17 Emmy nominations.
Braff also contrasted the vibrancy of JD to the subdued nature of his Garden State character Andrew Langham by noting he instills a little of his own personality in each role he plays.
"They're all a part of me. Scrubs' JD is very much me. I'm a very goofy, silly nerd," he teased. "But I have a quiet side that's very much Garden State.
"I always say acting is like adjusting different levels on a mixing board, you know? So Scrubs is just cranking the goofy, silly side of myself, and [my character in new movie High Cost of Living] is pulling all of that down and cranking the pensive, lonesome aspects of my personality."
The High Cost of Living, which co-stars Isabelle Blais, is now playing in US cinemas. A UK release date has not yet been announced.
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Watch a trailer for The High Cost of Living below: