According to The Hollywood Reporter, the single-camera show will form a part of the network's fall 2011-12 schedule when it is announced next Monday.
The actress and singer also appeared to confirm the news herself on her official Twitter account, writing: "I am thrilled that our show got picked up & so excited to work with this great group of people!also know I'm getting humblebragged. whatevs. (sic)"
Deschanel's character in The New Girl is Jessica, a teacher who moves in with three men after she gets dumped.
Her co-stars in the pilot, which was originally titled Chicks and D**ks, were Jake M. Johnson, Max Greenfield and Damon Wayans Jr.
Deschanel's older sister Emily will also be seen again on Fox next autumn following the news that Bones has been picked up for a seventh season.
> Tube Talk: The 2011-12 season scorecard