The 42-year-old Aussie actress, whose television drama Brothers and Sisters was axed last weekend, said that the relocation is for her children Banjo, Matilda and Clementine.
Griffiths told The Daily Telegraph: "[It] is for the kids really. They love their cousins and their grandparents. We've been away for so long, it just feels like it's time to come home. I'll still work, but the Aussie TV and film industry feels really strong at the moment. I've worked hard for ten years and I don't want to be a lead on a TV show for a while after this."
Griffiths and her artist husband Andrew Taylor will reportedly move into their Palm Beach property to allow her to commence work on her directorial debut movie B Model.
Brothers and Sisters, which also starred Sally Field and Calista Flockhart, was cancelled as part of a major cull by US network ABC but was believed to have experienced a drastic ratings drop after Rob Lowe left the series at the end of the fourth season.
At the Logie Awards recently, Griffiths said that she would be "really sad" if the show was cancelled as the cast are not "ready to say goodbye to each other yet". She also said that she and Flockhart had a "sad moment" when they filmed the latest season just in case it was their last.
> Read our latest Showbiz news