Fox will guest as one of Larry David's New York City neighbours in an episode scheduled to air this summer.
The actor's ailment will take centre stage with David accusing Fox of acting "symptomatic just to annoy him - a whole passive-aggressive thing", the actor told TV Guide.
"He's complaining because I'm shuffling and making noise upstairs," Fox said. "It's very funny."
The improvised sitcom's eighth run will boast a host of other guest stars including Ricky Gervais, Richard Lewis, Rosie O'Donnell and Fox's former Family Ties father Michael Gross.
Fox indicated that he is particularly excited to see Gross portray David's put-upon dermatologist, adding: "I heard wonderful things about that [episode] when I was doing mine. They said it was really nutty."
Series regulars Cheryl Hines, Susie Essman and Jeff Garlin will return as well.
Curb Your Enthusiasm returns July 10 on HBO.
> Michael J. Fox: 'My life isn't over'
> Larry David boards The Three Stooges
Watch a behind-the scenes look at Curb Your Enthusiasm's eighth season below: