The Dawson's Creek alum will appear in an episode of the show this summer, TV Line reports.
Van Der Beek will play Rex Tamlyn, an arrogant playboy who is a partner in a social networking website.
The episode focuses on a lawsuit about a stolen idea and what happens when two bodies turn up in the company's office.
As well as starring in Dawson's Creek, Van Der Beek has also appeared in One Tree Hill and Mercy. He will play himself in ABC's new midseason comedy Apartment 23.
The Criminal Intent instalment will also feature guest appearances from Nikita star Thad Luckinbill and his twin Trent.
Adrian Pasdar, Bryan Batt, Raymond J. Barry and Cynthia Nixon have already signed up to star in the tenth and possibly final season of Law & Order: Criminal Intent.
The show airs on Sundays at 9/8c on USA.