The sixth season saw Nancy Botwin, played by Mary-Louise Parker, give herself over to the authorities for murder as her family fled to Amsterdam.
Showtime has revealed that the new season will pick up three years later, when Nancy is released from prison into a halfway house in New York City.
Justin Kirk, Hutner Parrish and Alexander Gould will all return as Andy, Silas and Shane respectively, while Kevin Nealon is also back as Nancy's pot-addicted accountant Doug Wilson.
Guest starring in the new season will be Saturday Night Live regular Martin Short, recurring in at least three episodes as an eccentric attorney, while Game of Thrones star Aidan Quinn will portray a corporate firm CEO in several episodes.
Lindsay Sloane will guest star as a potential new love interest for Andy, while Jennifer Jason Leigh is to reprise her role as Nancy's sister Jill in a four-episode arc.
The seventh season of Weeds begins on Showtime on June 27.