The new NBC comedy is based on the memoirs of comedian Chelsea Handler and stars Laura Prepon.
Handler, who executive produces the show and plays the older sister of Prepon's character, has now revealed that she has asked Barr to take on a guest role in the series.
"I'm talking to Roseanne Barr to do some guest episodes as my aunt," she told The Hollywood Reporter. "She's interested in doing it, so it should be fun."
Barr was reportedly originally considered for a role in the pilot which eventually went to Glee star Dot Jones. She is best known for her role in her own sitcom Roseanne.
Are You There, Vodka? It's Me, Chelsea will air on NBC in midseason.
Watch a trailer for Are You There, Vodka? It's Me, Chelsea below: