The Juno star has already recorded his lines for the episode, Entertainment Weekly reports.
He will play Nick, a potential love interest for Lisa.
"He starts quoting Hemingway and she says, 'You're not a product of the Springfield public schools, are you?'" explained executive producer Al Jean. "And he goes, 'No, I come to Springfield for the food and the women'.
"So he talks a good game. [But] she starts to realise that he's less than expected."
Cera has previously provided the voice for Sal in Children's Hospital. He has also appeared in movies like Youth In Revolt and Scott Pilgrim vs. The World and played George-Michael Bluth in the television show Arrested Development.
Cera's episode of The Simpsons is expected to air as part of the animation's 23rd season, which will begin this fall on Fox.
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