The original comedy-drama, which premieres on Channel 4 on Monday, June 27 at 10pm, stars Rhys Thomas, Kayvan Novak and Game of Thrones actor Richard Madden as a trio of young paramedics.
Rescue Me star Leary will co-write the half-hour US version alongside Wedding Crashers scribe Bob Fisher. Both men will also executive produce alongside Jim Serpico, Hal Vogel and David Aukin.
"We are still finding our way in the genre but we know for certain that our half hours will be written and produced by creators with a specific and unique point of view," said USA's senior vice-president of original scripted programming Bill McGoldrick.
"Since they formed [production company] Apostle, Denis and Jim have brought those two qualities to everything they've done."
The original Sirens was created by Brian Fillis and is based on EMT paramedic Tom Reynolds's book Blood, Sweat and Tea.
USA currently has a number of other pilot projects in development, including the hour-long Over/Under, comedy-drama Common Law, legal series Wild Card and con artist drama Eden.
> Sirens: Q&A with Richard Madden