The CBS series, which features a mixture of topical chat and celebrity guests, features Osbourne alongside a team of regulars including Julie Chen, Sara Gilbert, Leah Remini and Holly Robinson Peete.
The Talk will air daily at 7pm from Monday, July 4.
Guests in the first week include American Idol judge Jennifer Lopez, Jamie Lee Curtis and Hilary Swank. Barry Manilow, LL Cool J, Joan Collins and Cybill Shepherd will also appear in the opening month.
The Talk is executive produced by John Redmann and Sara Gilbert for Raquel Productions Inc.
> CBS's The Talk secures second season
> Sharon Osbourne: 'Dannii Minogue was thrown off X Factor'
Watch a clip of Sharon Osbourne speaking about weight struggles on The Talk below: