The project, which is a potential midseason show, focuses on three families whose children play little league sports.
Marshall and Boyar have now departed the comedy along with one of the child stars who worked on the pilot, Deadline says.
Boyar had played the husband of Alanna Ubach's character, who is now expected to be turned into a single mother.
Meanwhile, Marshall's character - the onscreen wife of Rob Corddry - is expected to be recast, as is the role of the departing child star.
Little In Common also stars Gabrielle Union and Kevin Hart.