George Harrison: Living In The Material World will air in two parts on October 5 and 6.
Scorsese's programme will examine the late Beatle's spiritual passions and his music through never-before-seen interviews and exclusive song clips.
Harrison's widow Olivia co-produced the project, which also features interviews with Yoko Ono, Eric Clapton, Phil Spector and George Martin.
The Raging Bull director previously produced the acclaimed Rolling Stones documentary Shine A Light.
Scorsese described Material World as "a joy" to make and an experience that he would "never forget".
"George was making spiritually awake music, we all heard and felt it, and I think that was the reason that he came to occupy a very special place in our lives," said the director.
Harrison died of lung cancer in 2001.
The documentary will be released in the UK on DVD by Lionsgate on October 10.
Watch George Harrison performing 'Bangladesh' during the concert for Bangladesh at 1971, Madison Square Garden below: