The crime drama was renewed for a tenth and supposedly final season in September 2010.
Series producer Chris Brancato suggested in May that the show could be picked up for an 11th season, provided that viewers showed enough interest for the final episodes.
However, USA co-president Jeff Wachtel has now confirmed that Law & Order: Criminal Intent is gone for good.
When asked if the show would be returning for season 11, Wachtel told TV Line: "No - and this is said with respect for the show, respect for Dick [Wolf], and most significantly with respect to the audience."
In June, Law & Order: Criminal Intent star Kathryn Erbe confessed that she was hoping for an 11th season of the crime drama, revealing that her co-star Vincent D'Onofrio was also keen to return.
Law & Order: Criminal Intent aired its final episode on June 26.