Isaacs has signed up to star in NBC's new midseason drama series Awake, which follows a man who begins to realise that he is living two parallel lives.
Isaacs has previously admitted that he is concerned the drama is too "high-concept" for the US networks.
The Black Hawk Down actor has now responded to a reader who wished him luck with the show, in an interview with Digital Spy.
"We need luck," he joked. "American network television is a very cutthroat business. If people don't watch you instantly out of the gate, you're cancelled."
However, Isaacs admitted that he has high hopes for the show, saying: "I just loved the pilot script. I hope we can keep the series as good as the pilot. I hope the writing and the acting and everything else keeps the standard up."
Isaacs, who played Lucius Malfoy in the Harry Potter films, recently provided the voice of Siddeley and Leland Turbo for new movie Cars 2.
> Jason Isaacs Twitter Q&A: Watch the video