Lee appeared in the show's pilot as a guest star but has now been upgraded to a full cast member, Deadline reports.
Suburgatory stars Jane Levy as a teenage girl called Tessa who is devastated when she is forced to move from Manhattan to the suburbs.
Lee will play Tessa's guidance counsellor Mr Wolf, who is said to be unaware of the nastier side of high school life.
Lee is perhaps best known for his role as Lloyd in Entourage, which recently began its eighth and final season.
Suburgatory, which will premiere on September 28 on ABC, also stars Ana Gasteyer, Cheryl Hines, Jeremy Sisto, Allie Grant and Alan Tudyk.
Watch a trailer for Suburgatory below: