The Good Wife star has previously appeared in two instalments of the show as Dr. Beverly Hofstadter, the mother of Leonard (Johnny Galecki).
The Big Bang Theory's executive producer Bill Prady has now told TV Line that she will reprise her role in the future, saying: "Christine is absolutely coming back."
Prady also revealed that he is hoping to secure some other previous guest stars for the new season.
"We certainly hope Laurie Metcalf will be back," he said. "And at some point, we'll have to see Wil Wheaton again."
Metcalf previously starred in three episodes as the mother of Sheldon (Jim Parsons), while Wheaton has played himself on the show three times.
The Big Bang Theory will return for a new season on September 22 on CBS.
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Watch a clip of Christine Baranski on The Big Bang Theory below: