The JAG star will appear in two episodes of the show's seventh season, according to TV Line.
Showrunner Erica Messer confirmed that Hofmann will play the first ex-wife of Agent Rossi (Joe Mantegna).
"She's the love of his life," explained the producer. "We'll meet her in episode five [of the new season]."
Hofmann previously starred on NBC's Dear John between 1988 and 1992, and later played Megan Russert on the same network's Homicide: Life on the Street.
The actress's recent television credits include guest appearances on NCIS, CSI: Miami and Curb Your Enthusiasm. Her Criminal Minds debut is currently expected to air in late October.
Mad Men actor Mark Moses will also appear on Criminal Minds as a US senator who targets the BAU team.
The seventh season of Criminal Minds will premiere on CBS on September 21.
> Criminal Minds cast changes helped show, says CBS exec
Watch a scene from Criminal Minds' sixth season finale below: