TBS announced that the late-night show had not been renewed for a third season yesterday, with its final episode slated to air tonight.
Lopez joked during his Wednesday night monologue: "Like almost every TV star who loses his job, now what am I going to do everybody asks... Like every TV star before me, I'm going to find some crack. I'm going to get on the pipe, lose that unwanted 110lbs I've been trying to lose."
He added: "I'm taking it good. I'm straight. I'm fine. My goddesses are a wreck... They left me... It's been great every night to work with the band... We're not saying goodbye, we're saying cable doesn't work!"
Watch George Lopez's penultimate monologue on Lopez Tonight below:
In the statement announcing the cancellation of Lopez Tonight yesterday, the network said: "We are proud to have partnered with George Lopez, who is an immensely talented comedian and entertainer. TBS has valued its partnership with George and appreciates all of his work on behalf of the network, both on and off the air."
Lopez Tonight premiered in November 2009.
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