The host of the E! pop culture round-up show said that while most celebrities that the show pokes fun at have a great sense of humour, the Kardashian family have been less understanding and have reacted negatively to the coverage in the past.
"I know the Kardashians don't like me. Reality stars without exception have come up to me and have said, 'Thank you for making fun of me'," McHale explained.
"We made so much fun of Jake Pavelka, and he responded by coming on the show. With the Kardashians, we're not allowed to say they have a sex tape anymore because the network flips out."
McHale also revealed that America's Next Top Model host Tyra Banks was particularly difficult when her talkshow The Tyra Banks Show was on the air.
The Community star recalled: "She was the only one that tried to make us not feature her show on ours, but then she changed her tune, and then she went off the air, much to our great disappointment."
McHale recently said that he is not a fan of reality TV and believes that such shows display human beings at their worst.