The 'You and I' singer declared that she is thrilled by the opportunity to be involved on the animated series, saying that it presents a different sort of challenge from making music.
"I make music, but I don't do voice-overs every day of the week, and their characters are so awesomely convincing and sincere and wild and funny, I had to remind myself constantly of the sincerity of the humour," GaGa told Entertainment Weekly.
"That's what I was trying to focus on, not putting on a character too much and really being as sincere as I could with the lines."
The 25-year-old teased the appearance, revealing that she heads to Springfield in order to help boost Lisa Simpson's confidence.
"I play a little bit of a sl*t," GaGa said. "The apple doesn't fall far from my artistic tree."
The singer described the experience of recording her lines as "one of the coolest things [she's] ever done", noting that someone close to her will be particularly excited by her appearance.
"My dad's probably going to do 80 backflips when the episode comes out," GaGa said.
The singer will open this year's MTV Video Music Awards, which are slated to air on Sunday, August 28 at 9pm. GaGa has promised that the performance will not disappoint.
Meanwhile, GaGa's Simpsons episode, titled 'Lisa Goes GaGa' will air in spring 2012 as a part of the series' 23rd season.
Watch a clip from the episode below: