The actress will appear in one episode of the show as a rich museum benefactor, TV Line says.
Her character ends up becoming a suspect in a murder investigation.
Tuck will star in the same episode of Castle as The Killing's Kristin Lehman, who recently signed up to play an art insurance investigator.
Tuck is currently playing Nan Flanagan in True Blood and has also appeared in shows including One Life To Live, Sunset Beach, Days of Our Lives and Saving Grace. She also recently had a role in the movie Super 8.
William Atherton, Michael Dorn and Penny Johnson Jerald are among the other stars who have signed up to appear in the new season of Castle, which premieres on September 19 on ABC.
Watch a preview of the fourth season of Castle below (contains season three spoilers):