Comedians Jon Lovitz, Patrice O'Neal and Amy Schumer, as well as actors Kate Walsh and William Shatner, will be joining the previously announced roasters Mike Tyson, Steve-O, Anthony Jeselnik, Jeffrey Ross and Harvey Levin for the September event.
Ex-Guns N' Roses guitarist Slash will also be making a special appearance at the event. The roast will be overseen by Family Guy creator Seth MacFarlane.
Sheen recently encouraged roasters to "bring it", saying that he hopes they will go beyond the more obvious jokes about the former Two and a Half Men star.
The actor was fired from the CBS sitcom in March after publicly feuding with series creator Chuck Lorre.
Sheen has since said that he wishes he could forget the past year, claiming that he looks forward to turning 46.
The roast will tape on Saturday, September 10, before airing opposite the premiere of Two and a Half Men.
Comedy Central's Roast of Charlie Sheen will premiere Monday, September 19 at 10pm ET/PT on Comedy Central.
Watch the teaser for The Comedy Central Roast of Charlie Sheen below (US only):