Blue Tilt will see the pair play two homicide detectives who struggle to balance their jobs with their erratic home lives, according to Deadline.
The project was originally conceived by Law & Order scribe Chris Brancato, who later developed the project alongside D'Onofrio and Hawke. All three will serve as executive producers.
Training Day star Hawke recently filmed rejected Fox pilot Exit Strategy, while D'onofrio's Law & Order: Criminal Intent concluded in June after a ten-year run.
The two actors also previously worked together on 2009 film Staten Island.
The initial Blue Tilt pilot will be produced by Universal Television and is expected to begin filming in New York by the end of the year.
Other drama projects currently in development at NBC include a wrestling show produced by Dwayne 'The Rock' Johnson, an adaptation of 1984 film Romancing the Stone and a modern-day update of Frankenstein.
A romantic drama from West Wing writer Michael Oates Palmer and a remake of Israeli series Pillars of Smoke are also in the works.
> More Television news