The In Plain Sight star will play a recurring character in at least three episodes of the show's upcoming second season.
According to Entertainment Weekly, Weller will portray a charismatic gallery curator who begins a romantic relationship with Bridget Moynahan's character Erin, only for her to discover he may a criminal.
Weller has also made guest appearances in Monk, Law & Order: Criminal Intent and more recently The Good Wife.
Blue Bloods executive producer Ed Zuckerman recently promised fans that the show will continue to focus on the Reagan family and their lives.
The show's new season sees Lie To Me star Monica Raymund take on a recurring role, while Dexter star David Ramsey will also appear.
Blue Bloods returns to CBS for its second season on Friday, September 23.
Watch a video recap of Blue Bloods season one below: